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dc.contributor.authorTemereanca, Simona
dc.contributor.authorHamalainen, Matti S.
dc.contributor.authorKuperberg, Gina R.
dc.contributor.authorStufflebeam, Steven M.
dc.contributor.authorHalgren, Eric
dc.contributor.authorBrown, Emery N.
dc.date.accessioned2012-12-10T16:12:04Z
dc.date.available2012-12-10T16:12:04Z
dc.date.issued2012-03
dc.date.submitted2011-11
dc.identifier.issn0270-6474
dc.identifier.issn1529-2401
dc.identifier.urihttp://hdl.handle.net/1721.1/75314
dc.description.abstractActive reading requires coordination between frequent eye movements (saccades) and short fixations in text. Yet, the impact of saccades on word processing remains unknown, as neuroimaging studies typically employ constant eye fixation. Here we investigate eye-movement effects on word recognition processes in healthy human subjects using anatomically constrained magnetoencephalography, psychophysical measurements, and saccade detection in real time. Word recognition was slower and brain responses were reduced to words presented early versus late after saccades, suggesting an overall transient impairment of word processing after eye movements. Response reductions occurred early in visual cortices and later in language regions, where they colocalized with repetition priming effects. Qualitatively similar effects occurred when words appeared early versus late after background movement that mimicked saccades, suggesting that retinal motion contributes to postsaccadic inhibition. Further, differences in postsaccadic and background-movement effects suggest that central mechanisms also contribute to postsaccadic modulation. Together, these results suggest a complex interplay between visual and central saccadic mechanisms during reading.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant HD050627)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant EB006385)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant DP1 OD003646)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant EB009048)en_US
dc.description.sponsorshipNational Center for Research Resources (U.S.) (Grant P41 RR14075)en_US
dc.description.sponsorshipMassachusetts General Hospital (Claflin Distinguished Scholars Award)en_US
dc.language.isoen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1523/jneurosci.5571-11.2012en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSFNen_US
dc.titleEye Movements Modulate the Spatiotemporal Dynamics of Word Processingen_US
dc.typeArticleen_US
dc.identifier.citationTemereanca, S. et al. “Eye Movements Modulate the Spatiotemporal Dynamics of Word Processing.” Journal of Neuroscience 32.13 (2012): 4482–4494.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.mitauthorTemereanca, Simona
dc.contributor.mitauthorHamalainen, Matti S.
dc.contributor.mitauthorStufflebeam, Steven M.
dc.contributor.mitauthorBrown, Emery N.
dc.relation.journalJournal of Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsTemereanca, S.; Hamalainen, M. S.; Kuperberg, G. R.; Stufflebeam, S. M.; Halgren, E.; Brown, E. N.en
dc.identifier.orcidhttps://orcid.org/0000-0003-2668-7819
dc.identifier.orcidhttps://orcid.org/0000-0001-6841-112X
mit.licensePUBLISHER_POLICYen_US


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