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Capacity analysis, cycle time optimization, and supply chain strategy in multi-product biopharmaceutical manufacturing operations
(Massachusetts Institute of Technology, 2011)
Application of system optimization theory, supply chain principles, and capacity modeling are increasingly valuable tools for use in pharmaceutical manufacturing facilities. The dynamics of the pharmaceutical industry - ...
Accelerating the development of complex products in extended enterprises
(Massachusetts Institute of Technology, 2011)
This thesis examines strategies to accelerate product development in a large commercial aerospace program structured as an extended enterprise where first and second tier suppliers perform most of the detailed product ...
Performance measurement system design for supply chain organizations
(Massachusetts Institute of Technology, 2011)
This thesis proposes a methodology to create an effective performance measurement system for an interconnected organization. The performance measurement system is composed of three components: a metrics set, a metrics ...
New product demand forecasting and distribution optimization : a case study at Zara
(Massachusetts Institute of Technology, 2011)
The problem of optimally distributing new products is common to many companies and industries. This thesis describes how this challenge was addressed at Zara, a leading retailer in the "fast fashion" industry. The thesis ...
Reducing enterprise IT fragmentation through standard metrics and decision tools : a case study in the aerospace and defense industry
(Massachusetts Institute of Technology, 2011)
Over the last several decades, manufacturing companies around the world have embraced new and powerful business tools made possible with Information Technology. Major investments are frequently made in enterprise-wide ...
Development of operations based long range network capacity planning models
(Massachusetts Institute of Technology, 2011)
Planning for vaccines manufacturing capacity is both a complex task requiring many inputs and an important function of manufacturers to ensure the supply of vaccines that prevent life-threatening illnesses. This thesis ...
Cost modeling for monoclonal antibody manufacturing
(Massachusetts Institute of Technology, 2011)
The Novartis BioPharmOps division is responsible for manufacturing large molecule products, including monoclonal antibodies, for late stage clinical trials and commercial sales. The BioPharmOps site in Huningue, France is ...
Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system
(Massachusetts Institute of Technology, 2011)
Previous studies of continuous manufacturing processes have used equipment-factored cost estimation methods to predict savings in initial plant investment costs. In order to challenge and validate the existing methods of ...
Improving customer order visibility to enable improved planning and decision making
(Massachusetts Institute of Technology, 2011)
The General Purpose Drives organization of ABB Switzerland does not capture sufficient data on the movement of customer orders through the production process to make efficient decisions on where to allocate improvement ...
Improving inventory and distribution in an aerospace parts and service organization
(Massachusetts Institute of Technology, 2011)
Hamilton Sundstrand has made several changes to their supply chain in recent years, including increased offshore and outsourced production, new service offerings and relocation of facilities, to meet shifting business needs ...