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Now showing items 21-30 of 46
Inventory optimization in high volume aerospace supply chains
(Massachusetts Institute of Technology, 2011)
The supply chains of aerospace products can be complex, involving thousands of components per product and hundreds of vendors spaced out over an increasingly global landscape. Managing all inputs necessary for these complex ...
Long range planning of biologics process development and clinical trial material supply process
(Massachusetts Institute of Technology, 2011)
This thesis investigates the feasibility of using a complex model with a Monte Carlo simulation model to forecast the financial, personnel, and manufacturing capacity resources needed for biologic drug development. Accurate ...
Strategic development of a manufacturing execution system (MES) for cold chain management using information product mapping
(Massachusetts Institute of Technology, 2011)
The Vaccines & Diagnostics (V&D) division of Novartis recently developed a global automation strategy that highlights the need to implement a manufacturing execution system (MES). Benefits of an MES (electronic production ...
Design for implementation : redesigning a planning process in a multinational company
(Massachusetts Institute of Technology, 2011)
As a consumer-packaged-goods company dealing with multiple suppliers, "Company X" (the company's real name has been disguised) has a clear need for an accurate raw material forecast. The current planning process has not ...
Corporate sustainability assessment methodology
(Massachusetts Institute of Technology, 2011)
Sustainability is a vague concept specifically in the context of a corporate world. There are numerous definitions for corporate sustainability and just as many ways of evaluating it. This work attempts to define, structure ...
Forecasting and planning for a multi-product seasonal production facility
(Massachusetts Institute of Technology, 2011)
With increasing cost pressure on commodity vaccine products, Novartis Vaccines & Diagnostics is continually looking for ways to improve operating efficiencies and decrease costs. As the largest drug product manufacturing ...
Optimization of shake inspections
(Massachusetts Institute of Technology, 2011)
The Boeing 737 program has recently announced an increase in the production rate from 31.5 airplanes per month to 35 airplanes per month. Throughout the production value stream, opportunities to improve quality and reduce ...
Lean transformation and relocation of jet engine assembly operations
(Massachusetts Institute of Technology, 2011)
As part of continuing lean transformation efforts at Pratt & Whitney, the Middletown Engine Center has turned its focus on the GP7000 turbofan engine as a target for lean implementation. Projected increases in GP7000 ...
M28 Fixed wing transport aircraft cost reduction
(Massachusetts Institute of Technology, 2011)
The M28 is a Polish short-takeoff-and-landing (STOL) light cargo aircraft developed in 1984 and currently built by PZL Mielec, a subsidiary of United Technology Corporation (UTC). There has been renewed interest in the ...
Forward thinking in reverse : design, implementation, and continuous monitoring of a closed-loop supply chain using optimization, simulation, and dashboard systems to maximize net recovery
(Massachusetts Institute of Technology, 2011)
Developed during our recent six-month engagement at Dell-a leading computer manufacturer and services provider with one of the world's leading supply chains--we discuss a network flow-based mixed-integer linear program ...