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Now showing items 31-40 of 831
Optimizing the sequenced production schedule by managing the internal supply chain
(Massachusetts Institute of Technology, 2006)
Many manufacturing companies wrestle with managing in-house manufactured inventories especially in the climate of Just-in-Time (JIT) manufacturing and with constant pressure to reduce inventory levels. One popular self-managing ...
Process optimization in drug discovery
(Massachusetts Institute of Technology, 2007)
Novartis is one of the largest pharmaceutical companies in the world, with their research headquarters (Novartis Institutes for BioMedical Research) located in Cambridge MA. In this thesis, I explore Novartis's process for ...
Supplier inventory and operations management process improvement methodology
(Massachusetts Institute of Technology, 2013)
The Building Construction Products (BCP) Division of Caterpillar makes 12 different loader, excavator, and tractor products with 10 manufacturing facilities worldwide. With relatively high volume machines, BCP saw that ...
Application of variation risk management processes in commercial aircraft design and manufacture
(Massachusetts Institute of Technology, 2004)
Companies and academics have known for many years that reducing variation in production processes can decrease production cost, increase product quality, and have substantial impact on overall profitability. Tools to help ...
Optimized distribution supply chain for improved customer service
(Massachusetts Institute of Technology, 2015)
In an attempt to attract consumers, companies are offering an increasingly wide range of product varieties to cater to each consumers individual needs and desires. This behavior leads to fragmentation of demand that increases ...
Optimizing the internal reuse of wireless network equipment
(Massachusetts Institute of Technology, 2013)
Reusing high-value wireless network equipment can allow telecommunications providers to achieve both financial and environmental benefits. However, without standardized processes and tools to reuse equipment, the reuse ...
Reducing government proposal procurement process complexity
(Massachusetts Institute of Technology, 2014)
US Aerospace Defense Vehicle Manufacturer (UADVM) sells Assembled Complex Equipment to the US Government through multi-year contracts. According to the Truth in Negotiations Act (TINA), such government defense contracts ...
Optimization of in-line semiconductor measurement rates : balancing cost and risk in a high mix, low volume environment
(Massachusetts Institute of Technology, 2004)
Due to a number of market development over the last decade, semiconductor manufacturing companies, including Intel Corporation, have added significant numbers of primarily high growth rate, high-mix, low-volume (HMLV) ...
Development of a risk management system for consumables used in biopharmaceutical manufacturing
(Massachusetts Institute of Technology, 2013)
Injectable drugs, like those manufactured by the BioPharmOps group of Novartis Pharmaceuticals AG, must conform to strict guidelines for purity and potency. Recent non-conformances of critical supplied consumables have ...
The pharmaco-economics of combination therapies : a study of the effects of component and market factors on combined therapy price
(Massachusetts Institute of Technology, 2006)
For a growing number of indications, combination therapies are becoming increasingly common due in part to their superior efficacy, as compared to monotherapies. In fact, in the case of infectious diseases such as AIDS and ...