Search
Now showing items 1-10 of 259
Dynamic control of Escherichia coli central metabolism for improvement of glucaric acid production
(Massachusetts Institute of Technology, 2015)
Metabolic engineering strategies have enabled improvements in yield and titer for a variety of valuable small molecules produced in microorganisms. Past approaches have been focused on up- and downregulation of genes to ...
Engineering nanostructured selective layers for reverse osmosis membranes
(Massachusetts Institute of Technology, 2015)
A major challenge to communities across the world in the next century will be ensuring millions have access to adequate freshwater resources. Studies from the UN World Health Organization indicate that over 1.1 billion ...
Simulation and control of dynamic directed self-assembly of nanostructures
(Massachusetts Institute of Technology, 2015)
Self-assembled nanoscale structures are the basis for various technological advancements in functional materials, sensors, and molecular circuits and factories. With significant progress in self-assembly of periodic ...
Stimuli-responsive self-assembling materials comprising amphiphilic copolymers for localized remotely triggered therapeutic delivery
(Massachusetts Institute of Technology, 2017)
The ability to introduce therapeutic at a specified location and time to a healing traumatic wound deep within the body by external non-invasive stimulus could provide great long-term benefit to patients. In this work, we ...
The study of bimolecular radical reactions using a novel time-resolved photoionization time-of-flight mass spectrometry and laser absorption spectrometry apparatus
(Massachusetts Institute of Technology, 2014)
This thesis discusses my work to design, build, troubleshoot, and utilize a novel experimental apparatus that is capable of quantitatively measuring the concentrations of reacting gas-phase species and their reactive ...
Improvement of D-glucaric acid production in Escherichia coli
(Massachusetts Institute of Technology, 2014)
D-glucaric acid is a naturally occurring compound which has been explored for a plethora of potential uses, including biopolymer production, cancer and diabetes treatment, cholesterol reduction, and as a replacement for ...
Mechanically flexible vapor-deposited polymeric thin films for electrochemical devices
(Massachusetts Institute of Technology, 2017)
The concept of self-powered wearable electronic system has been emerging. Such a system consists of three units: an intelligent end-user electronic device for exporting functions, an energy generation/conversion device ...
Microstructural manipulation and architecture design of carbon-based electrochemical systems
(Massachusetts Institute of Technology, 2014)
Carbon materials are important in electrochemistry. The often cited advantages of carbonaceous materials for electrochemical applications include wide potential working windows, tunable electrocatalytic activity for a ...
Automated feedback in flow for accelerated reaction screening, optimization, and kinetic parameter estimation
(Massachusetts Institute of Technology, 2015)
With the cost to discover and develop a drug now estimated to exceed $2 billion, the pharmaceutical industry is in search of innovative and cost-effective ways to reduce process footprint, minimize lead times, and accelerate ...
Study of the differential compartmentation and functions of hexokinase isoforms and implications for cancer metabolism
(Massachusetts Institute of Technology, 2017)
Selectivity is a very important consideration when designing cancer treatment. Therefore, targeting cancer-specific isoforms of key metabolic enzymes is a very promising strategy. Elevated glucose consumption and lactate ...