Removing human immunodeficiency virus (HIV) from human blood using immobilized heparin
Author(s)Nassar, Roger A.; Browne, Edward P.; Chen, Jianzhu; Klibanov, Alexander M.
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Heparin covalently attached to a water-insoluble resin suspended in HIV-infected aqueous buffer or whole blood captures the virus; subsequent physical separation of the immobilized heparin reduced the viral titers by over 80 and 50%, respectively. The detoxification concept has been validated by both circulating an HIV-1 solution through a column packed with the heparin–sepharose beads and successively mixing an HIV-1 solution with fresh beads.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemistry
Nassar, Roger A. et al. “Removing Human Immunodeficiency Virus (HIV) from Human Blood Using Immobilized Heparin.” Biotechnology Letters 34.5 (2011): 853–856.
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