| dc.contributor.author | Leduc, Andrew B. | |
| dc.contributor.author | Jamison, Timothy F. | |
| dc.date.accessioned | 2013-01-17T17:27:09Z | |
| dc.date.available | 2013-01-17T17:27:09Z | |
| dc.date.issued | 2011-06 | |
| dc.date.submitted | 2011-04 | |
| dc.identifier.issn | 1083-6160 | |
| dc.identifier.issn | 1520-586X | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/76284 | |
| dc.description.abstract | We report a method for the oxidation of a range of alcohols and aldehydes utilizing a simple flow system of alcohols in EtOAc with a stream of 12.5% NaOCl and catalytic Bu[subscript 4]NBr. Secondary alcohols are oxidized to ketones, aldehydes are oxidized directly to methyl esters in the presence of methanol, and benzylic alcohols are oxidized to either benzaldehydes or methyl esters, depending on the conditions used. The reaction conditions are mild and generally provide complete conversion in 5–30 min. | en_US |
| dc.description.sponsorship | Novartis-MIT Center for Continuous Manufacturing | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/op200118h | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Prof. Jamison via Erja Kajosalo | en_US |
| dc.title | Continuous Flow Oxidation of Alcohols and Aldehydes Utilizing Bleach and Catalytic Tetrabutylammonium Bromide | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Leduc, Andrew B., and Timothy F. Jamison. “Continuous Flow Oxidation of Alcohols and Aldehydes Utilizing Bleach and Catalytic Tetrabutylammonium Bromide.” Organic Process Research & Development 16.5 (2012): 1082–1089. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.approver | Jamison, Timothy F. | |
| dc.contributor.mitauthor | Leduc, Andrew B. | |
| dc.contributor.mitauthor | Jamison, Timothy F. | |
| dc.relation.journal | Organic Process Research & Development | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Leduc, Andrew B.; Jamison, Timothy F. | en |
| dc.identifier.orcid | https://orcid.org/0000-0002-8601-7799 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
