| dc.contributor.author | Webb, Damien | |
| dc.contributor.author | Jamison, Timothy F. | |
| dc.date.accessioned | 2013-01-17T18:25:17Z | |
| dc.date.available | 2013-01-17T18:25:17Z | |
| dc.date.issued | 2011-12 | |
| dc.date.submitted | 2011-11 | |
| dc.identifier.issn | 1523-7060 | |
| dc.identifier.issn | 1523-7052 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/76286 | |
| dc.description.abstract | A continuous flow system for the multiparameter (flow rate, temperature, residence time, stoichiometry) optimization of the DIBALH reduction of esters to aldehydes is described. Incorporating an in-line quench (MeOH), these transformations are generally complete in fewer than 60 s. Mixing of the DIBALH and ester solutions was observed to be an exceptionally critical parameter for optimum results. This system thus provides general guidelines based on the structure of the ester for selective reduction of an ester without overreduction. | en_US |
| dc.description.sponsorship | Novartis-MIT Center for Continuous Manufacturing | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ol2031872 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Prof. Jamison via Erja Kajosalo | en_US |
| dc.title | Diisobutylaluminum Hydride Reductions Revitalized: A Fast, Robust, and Selective Continuous Flow System for Aldehyde Synthesis | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Webb, Damien, and Timothy F. Jamison. “Diisobutylaluminum Hydride Reductions Revitalized: A Fast, Robust, and Selective Continuous Flow System for Aldehyde Synthesis.” Organic Letters 14.2 (2012): 568–571. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.approver | Jamison, Timothy F. | |
| dc.contributor.mitauthor | Webb, Damien | |
| dc.contributor.mitauthor | Jamison, Timothy F. | |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Webb, Damien; Jamison, Timothy F. | en |
| dc.identifier.orcid | https://orcid.org/0000-0002-8601-7799 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
