One-Flow, Multi-Step Synthesis of Nucleosides via Brønsted Acid- Catalyzed Glycosylation

Author(s)
Sniady, Adam; Bedore, Matthew W.; Jamison, Timothy F.
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Abstract
Nucleosides in flow: A general, scalable method of Brønsted acid-catalyzed nucleoside formation is described. Because of the high reaction temperatures readily available to the flow reaction format, mild Brønsted acids, particularly pyridinium triflates, can be used. A one-flow multistep synthesis of unprotected nucleosides is also reported (see scheme).
Date issued
2011-01
URI
http://hdl.handle.net/1721.1/76287
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Sniady, Adam, Matthew W. Bedore, and Timothy F. Jamison. “One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation.” Angewandte Chemie International Edition 50.9 (2011): 2155–2158.
Version: Author's final manuscript
ISSN
1433-7851
1521-3773
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