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Glycosylation at Asn[supscript 91] of H1N1 haemagglutinin affects binding to glycan receptors

Author(s)
Jayaraman, Akila; Koh, Xiaoying; Li, Jing; Raman, Rahul; Viswanathan, Karthik; Shriver, Zachary H.; Sasisekharan, Ram; ... Show more Show less
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Abstract
The glycoprotein HA (haemagglutinin) on the surface of influenza A virus plays a central role in recognition and binding to specific host cell-surface glycan receptors and in fusion of viral membrane to the host nuclear membrane during viral replication. Given the abundance of HA on the viral surface, this protein is also the primary target for host innate and adaptive immune responses. Although addition of glycosylation sites on HA are a part of viral evolution to evade the host immune responses, there are specific glycosylation sites that are conserved during most of the evolution of the virus. In the present study, it was demonstrated that one such conserved glycosylation site at Asn[superscript 91] in H1N1 HA critically governs the glycan receptor-binding specificity and hence would potentially impinge on the host adaptation of the virus.
Date issued
2012-05
URI
http://hdl.handle.net/1721.1/76307
Department
David H. Koch Institute for Integrative Cancer Research at MIT; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. School of Engineering
Journal
Biochemical Journal
Publisher
Portland Press
Citation
Jayaraman, Akila et al. “Glycosylation at Asn [superscript 91] of H1N1 Haemagglutinin Affects Binding to Glycan Receptors.” Biochemical Journal 444.3 (2012).
Version: Final published version
ISSN
0264-6021
1470-8728

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