Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation
Author(s)
Soundararajan, Venkataramanan; Patel, Neel; Warnock, Ken; Wilson, Ian A.; Raguram, S.; Sasisekharan, V.; Sasisekharan, Ram; Zheng, Shu, M. Eng. Massachusetts Institute of Technology; Raman, Rahul; ... Show more Show less
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Influenza viral passaging through pre-vaccinated mice shows that emergent antigenic site mutations on the viral hemagglutinin (HA) impact host receptor-binding affinity and, therefore, the evolution of fitter influenza strains. To understand this phenomenon, we computed the Significant Interactions Network (SIN) for each residue and mapped the networks of antigenic site residues on a representative H1N1 HA. Specific antigenic site residues are ‘linked’ to receptor-binding site (RBS) residues via their SIN and mutations within “RBS-linked” antigenic residues can significantly influence receptor-binding affinity by impacting the SIN of key RBS residues. In contrast, other antigenic site residues do not have such “RBS-links” and do not impact receptor-binding affinity upon mutation. Thus, a potential mechanism emerges for how immunologic pressure on RBS-linked antigenic residues can contribute to evolution of fitter influenza strains by modulating the host receptor-binding affinity.
Date issued
2011-12Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Singapore-MIT Alliance in Research and Technology (SMART); Koch Institute for Integrative Cancer Research at MITJournal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Soundararajan, Venkataramanan et al. “Networks Link Antigenic and Receptor-binding Sites of Influenza Hemagglutinin: Mechanistic Insight into Fitter Strain Propagation.” Scientific Reports 1 (2011): Web.
Version: Final published version
ISSN
2045-2322