dc.contributor.author | Zaborenko, Nikolay | |
dc.contributor.author | Bedore, Matthew W. | |
dc.contributor.author | Jamison, Timothy F. | |
dc.contributor.author | Jensen, Klavs F. | |
dc.date.accessioned | 2013-02-15T19:54:55Z | |
dc.date.available | 2013-02-15T19:54:55Z | |
dc.date.issued | 2011-01 | |
dc.date.submitted | 2010-09 | |
dc.identifier.issn | 1083-6160 | |
dc.identifier.issn | 1520-586X | |
dc.identifier.uri | http://hdl.handle.net/1721.1/77156 | |
dc.description.abstract | A continuous-flow microreactor is applied for a kinetic study of a model β-amino alcohol
formation by epoxide aminolysis. A large number of experiments are performed in a short time
with minimal reagent consumption. The kinetics of formation of secondary aminolysis between
starting epoxide and product are decoupled from the primary synthesis, constructing a complete
model for desired product formation. The activation energy for the formation of desired product
is observed to be higher than those for regioisomer formation and for secondary aminolysis,
indicating that increasing temperature improves selectivity in addition to accelerating the
reaction. A set of optimized conditions is then selected for best reaction performance, and a
scaled-up process is performed, demonstrating improvement on a meso-scale. | en_US |
dc.description.sponsorship | Novartis-MIT Center for Continuous Manufacturing | en_US |
dc.language.iso | en_US | |
dc.publisher | American Chemical Society | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1021/op100252m | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | Prof. Jamison via Erja Kajosalo | en_US |
dc.title | Mechanistic Investigations of Epoxide Aminolysis in Microreactors at High Temperatures and Pressures | en_US |
dc.title.alternative | Kinetic and Scale-up Investigations of Epoxide Aminolysis in Microreactors at High Temperatures and Pressures | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Zaborenko, Nikolay et al. “Kinetic and Scale-Up Investigations of Epoxide Aminolysis in Microreactors at High Temperatures and Pressures.” Organic Process Research & Development 15.1 (2011): 131–139. Web. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.approver | Jamison, Timothy F. | |
dc.contributor.mitauthor | Jamison, Timothy F. | |
dc.contributor.mitauthor | Jensen, Klavs F. | |
dc.contributor.mitauthor | Zaborenko, Nikolay | |
dc.contributor.mitauthor | Bedore, Matthew W. | |
dc.relation.journal | Organic Process Research & Development | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Zaborenko, Nikolay; Bedore, Matthew W.; Jamison, Timothy F.; Jensen, Klavs F. | en |
dc.identifier.orcid | https://orcid.org/0000-0001-7192-580X | |
dc.identifier.orcid | https://orcid.org/0000-0002-8601-7799 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |