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dc.contributor.authorPainter, Michio W.
dc.contributor.authorDavis, Scott
dc.contributor.authorHardy, Richard R.
dc.contributor.authorMathis, Diane
dc.contributor.authorBenoist, Christophe
dc.contributor.authorImmunological Genome Project Consortium
dc.date.accessioned2013-02-21T19:58:49Z
dc.date.available2013-02-21T19:58:49Z
dc.date.issued2011-02
dc.date.submitted2010-08
dc.identifier.issn0022-1767
dc.identifier.issn1550-6606
dc.identifier.urihttp://hdl.handle.net/1721.1/77188
dc.description.abstractT and B lymphocytes are developmentally and functionally related cells of the immune system, representing the two major branches of adaptive immunity. Although originating from a common precursor, they play very different roles: T cells contribute to and drive cell-mediated immunity, whereas B cells secrete Abs. Because of their functional importance and well-characterized differentiation pathways, T and B lymphocytes are ideal cell types with which to understand how functional differences are encoded at the transcriptional level. Although there has been a great deal of interest in defining regulatory factors that distinguish T and B cells, a truly genomewide view of the transcriptional differences between these two cells types has not yet been taken. To obtain a more global perspective of the transcriptional differences underlying T and B cells, we exploited the statistical power of combinatorial profiling on different microarray platforms, and the breadth of the Immunological Genome Project gene expression database, to generate robust differential signatures. We find that differential expression in T and B cells is pervasive, with the majority of transcripts showing statistically significant differences. These distinguishing characteristics are acquired gradually, through all stages of B and T differentiation. In contrast, very few T versus B signature genes are uniquely expressed in these lineages, but are shared throughout immune cells.en_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (U.S.) (National Institutes of Health (R24 AI072073)en_US
dc.language.isoen_US
dc.publisherAmerican Association of Immunologists, Inc.en_US
dc.relation.isversionofhttp://dx.doi.org/10.4049/jimmunol.1002695en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePMCen_US
dc.titleTranscriptomes of the B and T lineages compared by multiplatform microarray profilingen_US
dc.typeArticleen_US
dc.identifier.citationPainter, M. W. et al. “Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling.” The Journal of Immunology 186.5 (2011): 3047–3057. CrossRef. Web.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorRegev, Aviv
dc.relation.journalJournal of Immunologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsPainter, M. W.; Davis, S.; Hardy, R. R.; Mathis, D.; Benoist, C.en
dc.identifier.orcidhttps://orcid.org/0000-0001-8567-2049
dspace.mitauthor.errortrue
mit.licenseOPEN_ACCESS_POLICYen_US


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