Pathological crystallization of human immunoglobulins

Author(s)
Wang, Ying; Lomakin, Aleksey; Hideshima, Teru; Laubach, Jacob P.; Ogun, Olutayo; ... Show more
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Abstract
Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations. This suggests that, even within the regular immune response to infections, cryoprecipitation of Ig can be possible.
Date issued
2012-07
URI
http://hdl.handle.net/1721.1/77567
Department
MIT Materials Research Laboratory; Massachusetts Institute of Technology. Department of Materials Science and Engineering; Massachusetts Institute of Technology. Department of Physics
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Wang, Y. et al. “Pathological Crystallization of Human Immunoglobulins.” Proceedings of the National Academy of Sciences 109.33 (2012): 13359–13361. © 2012 National Academy of Sciences
Version: Final published version
ISSN
0027-8424
1091-6490
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