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dc.contributor.authorLi, Na
dc.contributor.authorYin, Lu
dc.contributor.authorThevenin, Damien
dc.contributor.authorYamada, Yoshiyuki
dc.contributor.authorLimmon, Gino V.
dc.contributor.authorChen, Jianzhu
dc.contributor.authorChow, Vincent T. K.
dc.contributor.authorEngelman, Donald M.
dc.contributor.authorEngelward, Bevin P.
dc.date.accessioned2013-03-15T16:16:51Z
dc.date.available2013-03-15T16:16:51Z
dc.date.issued2013-02
dc.identifier.issn1746-0913
dc.identifier.issn1746-0921
dc.identifier.urihttp://hdl.handle.net/1721.1/77907
dc.description.abstractIn this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. Materials & methods: Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. Results: pHLIP specifically targeted inflamed lung tissues of infected mice in the later stages of disease and at sites where alveolar type I and type II cells were depleted. Regions of pHLIP-targeted lung tissue were devoid of peroxiredoxin 6, the lung-abundant antioxidant enzyme, and were deficient in pneumocytes. Interestingly, a pHLIP variant possessing mutations that render it insensitive to pH changes was also able to target damaged lung tissue. Conclusion: pHLIP holds potential for delivering therapeutics for lung injury during influenza infection. Furthermore, there may be more than one mechanism that enables pHLIP variants to target inflamed lung tissue.en_US
dc.description.sponsorshipNational Institute of Environmental Health Sciences (P01 - ES006052)en_US
dc.description.sponsorshipSingapore–MIT Alliance for Research and Technologyen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant GM073857)en_US
dc.language.isoen_US
dc.publisherFuture Medicineen_US
dc.relation.isversionofhttp://dx.doi.org/10.2217/fmb.12.134en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourceProf. Engelward via Howarden_US
dc.titlePeptide targeting and imaging of damaged lung tissue in influenza-infected miceen_US
dc.typeArticleen_US
dc.identifier.citationLi, Na et al. “Peptide Targeting and Imaging of Damaged Lung Tissue in Influenza-infected Mice.” Future Microbiology 8.2 (2013): 257–269. CrossRef. Web.en_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentSingapore-MIT Alliance in Research and Technology (SMART)en_US
dc.contributor.approverEngelward, Bevin P.
dc.contributor.mitauthorEngelward, Bevin P.
dc.contributor.mitauthorLi, Na
dc.contributor.mitauthorYin, Lu
dc.contributor.mitauthorYamada, Yoshiyuki
dc.contributor.mitauthorChen, Jianzhu
dc.contributor.mitauthorLimmon, Gino V.
dc.relation.journalFuture Microbiologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLi, Na; Yin, Lu; Thévenin, Damien; Yamada, Yoshiyuki; Limmon, Gino; Chen, Jianzhu; Chow, Vincent TK; Engelman, Donald M; Engelward, Bevin Pen
dc.identifier.orcidhttps://orcid.org/0000-0002-5687-6154
dspace.mitauthor.errortrue
mit.licenseOPEN_ACCESS_POLICYen_US


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