dc.contributor.author | Merrikh, Houra | |
dc.contributor.author | Zhang, Yan | |
dc.contributor.author | Wang, Jue D. | |
dc.contributor.author | Grossman, Alan Davis | |
dc.date.accessioned | 2013-03-15T17:54:35Z | |
dc.date.available | 2013-03-15T17:54:35Z | |
dc.date.issued | 2012-07 | |
dc.identifier.issn | 1740-1526 | |
dc.identifier.issn | 1740-1534 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/77912 | |
dc.description.abstract | DNA replication and transcription use the same template and occur concurrently in bacteria. The lack of temporal and spatial separation of these two processes leads to their conflict, and failure to deal with this conflict can result in genome alterations and reduced fitness. In recent years major advances have been made in understanding how cells avoid conflicts between replication and transcription and how such conflicts are resolved when they do occur. In this Review, we summarize these findings, which shed light on the significance of the problem and on how bacterial cells deal with unwanted encounters between the replication and transcription machineries. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (grant GM084003) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (grant GM41934) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (postdoctoral fellowship GM093408) | en_US |
dc.description.sponsorship | University of Washington. Department of Microbiology | en_US |
dc.description.sponsorship | Cancer Prevention and Research Institute of Texas (Training Program grant RP101499) | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/nrmicro2800 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike 3.0 | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | en_US |
dc.source | Grossman via Courtney Crummett | en_US |
dc.title | Replication–transcription conflicts in bacteria | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Merrikh, Houra et al. “Replication–transcription Conflicts in Bacteria.” Nature Reviews Microbiology (2012): p.449-458. CrossRef. Web. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.approver | Grossman, Alan D. | |
dc.contributor.mitauthor | Grossman, Alan D. | |
dc.relation.journal | Nature Reviews. Microbiology | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Merrikh, Houra; Zhang, Yan; Grossman, Alan D.; Wang, Jue D. | en |
dc.identifier.orcid | https://orcid.org/0000-0002-8235-7227 | |
mit.license | OPEN_ACCESS_POLICY | en_US |
mit.metadata.status | Complete | |