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dc.contributor.authorVecchio, Domitilla Del
dc.date.accessioned2013-04-09T19:01:27Z
dc.date.available2013-04-09T19:01:27Z
dc.date.issued2012-08
dc.date.submitted2012-01
dc.identifier.issn1478-3967
dc.identifier.issn1478-3975
dc.identifier.urihttp://hdl.handle.net/1721.1/78305
dc.description.abstractModularity is a property by which the behavior of a system does not change upon interconnection. It is crucial for understanding the behavior of a complex system from the behavior of the composing subsystems. Whether modularity holds in biology is an intriguing and largely debated question. In this paper, we discuss this question taking a control system theory view and focusing on signaling systems. In particular, we argue that, despite signaling systems being constituted of structural modules, such as covalent modification cycles, modularity does not hold in general. As in any engineering system, impedance-like effects, called retroactivity, appear at interconnections and alter the behavior of connected modules. We further argue that while signaling systems have evolved sophisticated ways to counter-act retroactivity and enforce modularity, retroactivity may also be exploited to finely control the information processing of signaling pathways. Testable predictions and experimental evidence are discussed with their implications.en_US
dc.language.isoen_US
dc.publisherIOP Publishingen_US
dc.relation.isversionofhttp://dx.doi.org/10.1088/1478-3975/9/4/045008en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourceMIT web domainen_US
dc.titleModularity in signaling systemsen_US
dc.typeArticleen_US
dc.identifier.citationVecchio, Domitilla Del. “Modularity in Signaling Systems.” Physical Biology 9.4 (2012): 045008.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.mitauthorVecchio, Domitilla Del
dc.relation.journalPhysical Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsVecchio, Domitilla Delen
dc.identifier.orcidhttps://orcid.org/0000-0001-6472-8576
mit.licenseOPEN_ACCESS_POLICYen_US


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