Retroactivity attenuation in signaling cascades
Author(s)Ossareh, Hamid R.; Del Vecchio, Domitilla
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It has been shown in an earlier work that impedance-like effects, called retroactivity, are found at the interconnection of biomolecular systems just as they occur in several engineering systems. These effects are particularly relevant in signaling cascades that have several downstream targets. These cascades have been extensively studied to determine how a stimulus at the top of the cascade is transmitted and amplified as it propagates toward the bottom of the cascade. In principle, because of retroactivity, a perturbation at the bottom of the cascade can propagate upstream. In this paper, we study the extent to which this propagation occurs by analytically finding retroactivity gains at each stage of the cascade. These gains determine whether a perturbation at the bottom of the cascade is amplified or attenuated as it propagates upstream.
DepartmentMassachusetts Institute of Technology. Department of Mechanical Engineering
Proceedings of the 50th IEEE Conference on Decision and Control and European Control Conference (CDC-ECC), 2011
Institute of Electrical and Electronics Engineers (IEEE)
Ossareh, Hamid R., and Domitilla Del Vecchio. “Retroactivity Attenuation in Signaling Cascades.” IEEE, 2011. 2220–2226.
Author's final manuscript