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dc.contributor.authorDiephuis, Bradford J.
dc.contributor.authorTearney, Guillermo J.
dc.contributor.authorLiu, Linbo
dc.contributor.authorChu, Kengyeh K.
dc.contributor.authorHouser, Grace H.
dc.contributor.authorLi, Yao
dc.contributor.authorWilsterman, Eric J.
dc.contributor.authorShastry, Suresh
dc.contributor.authorDierksen, Gregory
dc.contributor.authorBirket, Susan E.
dc.contributor.authorBirket, Susan E.
dc.contributor.authorByan-Parker, Suzanne
dc.contributor.authorGrizzle, William E.
dc.contributor.authorSorscher, Eric J.
dc.contributor.authorRowe, Steven M.
dc.date.accessioned2013-04-17T16:53:04Z
dc.date.available2013-04-17T16:53:04Z
dc.date.issued2013-01
dc.date.submitted2012-10
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/78568
dc.description.abstractWe demonstrate the use of a high resolution form of optical coherence tomography, termed micro-OCT (μOCT), for investigating the functional microanatomy of airway epithelia. μOCT captures several key parameters governing the function of the airway surface (airway surface liquid depth, periciliary liquid depth, ciliary function including beat frequency, and mucociliary transport rate) from the same series of images and without exogenous particles or labels, enabling non-invasive study of dynamic phenomena. Additionally, the high resolution of μOCT reveals distinguishable phases of the ciliary stroke pattern and glandular extrusion. Images and functional measurements from primary human bronchial epithelial cell cultures and excised tissue are presented and compared with measurements using existing gold standard methods. Active secretion from mucus glands in tissue, a key parameter of epithelial function, was also observed and quantified.en_US
dc.language.isoen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0054473en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/en_US
dc.sourcePLoSen_US
dc.titleMethod for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomographyen_US
dc.typeArticleen_US
dc.identifier.citationLiu, Linbo et al. “Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomography.” Ed. Michael Myerburg. PLoS ONE 8.1 (2013): e54473.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorDiephuis, Bradford J.
dc.contributor.mitauthorTearney, Guillermo J.
dc.relation.journalPLoS ONEen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLiu, Linbo; Chu, Kengyeh K.; Houser, Grace H.; Diephuis, Bradford J.; Li, Yao; Wilsterman, Eric J.; Shastry, Suresh; Dierksen, Gregory; Birket, Susan E.; Mazur, Marina; Byan-Parker, Suzanne; Grizzle, William E.; Sorscher, Eric J.; Rowe, Steven M.; Tearney, Guillermo J.en
dc.identifier.orcidhttps://orcid.org/0000-0002-3402-6634
mit.licensePUBLISHER_CCen_US


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