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dc.contributor.authorWissner-Gross, Zachary D.
dc.contributor.authorScott, Mark Andrew
dc.contributor.authorSteinmeyer, Joseph Daly
dc.contributor.authorYanik, Mehmet Fatih
dc.date.accessioned2013-04-23T20:29:49Z
dc.date.available2013-04-23T20:29:49Z
dc.date.issued2013-02
dc.date.submitted2012-03
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/78578
dc.description.abstractAs neurons develop, several immature processes (i.e., neurites) grow out of the cell body. Over time, each neuron breaks symmetry when only one of its neurites grows much longer than the rest, becoming an axon. This symmetry breaking is an important step in neurodevelopment, and aberrant symmetry breaking is associated with several neuropsychiatric diseases, including schizophrenia and autism. However, the effects of neurite count in neuronal symmetry breaking have never been studied. Existing models for neuronal polarization disagree: some predict that neurons with more neurites polarize up to several days later than neurons with fewer neurites, while others predict that neurons with different neurite counts polarize synchronously. We experimentally find that neurons with different neurite counts polarize synchronously. We also show that despite the significant differences among the previously proposed models, they all agree with our experimental findings when the expression levels of the proteins responsible for symmetry breaking increase with neurite count. Consistent with these results, we observe that the expression levels of two of these proteins, HRas and shootin1, significantly correlate with neurite count. This coordinated symmetry breaking we observed among neurons with different neurite counts may be important for synchronized polarization of neurons in developing organisms.en_US
dc.language.isoen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0054905en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/en_US
dc.sourcePLoSen_US
dc.titleSynchronous Symmetry Breaking in Neurons with Different Neurite Countsen_US
dc.typeArticleen_US
dc.identifier.citationWissner-Gross, Zachary D. et al. “Synchronous Symmetry Breaking in Neurons with Different Neurite Counts.” Ed. Michal Zochowski. PLoS ONE 8.2 (2013): e54905.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.mitauthorWissner-Gross, Zachary D.
dc.contributor.mitauthorScott, Mark Andrew
dc.contributor.mitauthorSteinmeyer, Joseph Daly
dc.contributor.mitauthorYanik, Mehmet Fatih
dc.relation.journalPLoS ONEen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsWissner-Gross, Zachary D.; Scott, Mark A.; Steinmeyer, Joseph D.; Yanik, Mehmet Fatihen
dc.identifier.orcidhttps://orcid.org/0000-0001-8946-8205
mit.licensePUBLISHER_CCen_US


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