Tuning an activator-repressor clock employing retroactivity
Author(s)Rosenberg, Alexander; Jayanthi, Shridhar; Del Vecchio, Domitilla
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Activator-repressor systems have been shown to be capable of oscillations and are therefore an important clock motif in the field of Synthetic and Systems Biology. In this paper, we propose a method to regulate oscillatory behavior in such systems by the addition of DNA binding sites for the proteins involved in the clock network. We show that the retroactivity effect caused by this addition can effectively change the relative timescales among the protein dynamics and impact the behavior of the clock. We also employ root locus analysis to obtain a graphical interpretation of the results.
DepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Mechanical Engineering
Proceedings of the 2011 American Control Conference (ACC)
American Automatic Control Council
Rosenberg, Alexander, Shridhar Jayanthi and Domitilla Del Vecchio. "Tuning an activator-repressor clock employing retroactivity" In 2011 American Control Conference on O'Farrell Street, San Francisco, CA, USA June 29 - July 01, 2011. Proceedings. IEEE. 2011.
Author's final manuscript