Localized Delivery of Dexamethasone from Electrospun Fibers Reduces the Foreign Body Response
Author(s)
Vacanti, Nathaniel M.; Cheng, Hao; Hill, Paulina Sierpinski; Guerreiro, Joao D. T.; Dang, Tram T.; Ma, Minglin; Watson, Shanee; Hwang, Nathaniel S.; Langer, Robert; Anderson, Daniel Griffith; ... Show more Show less
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Synthetic scaffolds are crucial to applications in regenerative medicine; however, the foreign body response can impede regeneration and may lead to failure of the implant. Herein we report the development of a tissue engineering scaffold that allows attachment and proliferation of regenerating cells while reducing the foreign body response by localized delivery of an anti-inflammatory agent. Electrospun fibers composed of poly(l-lactic) acid (PLLA) and poly(ε-caprolactone) (PCL) were prepared with and without the steroid anti-inflammatory drug, dexamethasone. Analysis of subcutaneous implants demonstrated that the PLLA fibers encapsulating dexamethasone evoked a less severe inflammatory response than the other fibers examined. They also displayed a controlled release of dexamethasone over a period of time conducive to tissue regeneration and allowed human mesenchymal stem cells to adhere to and proliferate on them in vitro. These observations demonstrate their potential as a building block for tissue engineering scaffolds.
Date issued
2012-08Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MITJournal
Biomacromolecules
Publisher
American Chemical Society
Citation
Vacanti, Nathaniel M., Hao Cheng, Paulina S. Hill, et al. 2012 Localized Delivery of Dexamethasone from Electrospun Fibers Reduces the Foreign Body Response. Biomacromolecules 13(10): 3031–3038. © 2012 American Chemical Society.
Version: Final published version
ISSN
1525-7797
1526-4602