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dc.contributor.authorSchmidt, Daniel J.
dc.contributor.authorMoskowitz, Joshua Seth
dc.contributor.authorHammond, Paula T.
dc.date.accessioned2013-05-31T16:10:15Z
dc.date.available2013-05-31T16:10:15Z
dc.date.issued2010-11
dc.identifier.issn0897-4756
dc.identifier.issn1520-5002
dc.identifier.urihttp://hdl.handle.net/1721.1/79054
dc.descriptionAvailable in PMC 2011 December 14.en_US
dc.description.abstractElectrically triggered drug delivery represents an attractive option for actively and remotely controlling the release of a therapeutic from an implantable device (e.g., a “pharmacy-on-a-chip”). Here we report the fabrication of nanoscale thin films that can release precise quantities of a small molecule drug in response to application of a small, anodic electric potential of at least +0.5 V versus Ag/AgCl. Films containing negatively charged Prussian Blue (PB) nanoparticles and positively charged gentamicin, a small hydrophilic antibiotic, were fabricated using layer-by-layer (LbL) assembly. When oxidized, the PB nanoparticles shift from negatively charged to neutral, inducing dissolution of the film. Films with thicknesses in the range 100−500 nm corresponding to drug loadings of 1−4 μg/cm2 were characterized. We demonstrate control over the drug dosage by tuning the film thickness as well as the magnitude of the applied voltage. Drug release kinetics ranging from triggered burst release to on/off, or pulsatile release, were achieved by applying different electric potential profiles. Finally, the in vitro efficacy of the released drug was confirmed against Staphylococcus aureus bacteria. Given the versatility of an external electrical stimulus and the ability of the LbL assembly to conformally coat a variety of substrates regardless of size, shape, or chemical composition, we maintain that electrically controlled release of a drug from an LbL-coated surface could have applications in both implantable medical devices and transdermal drug delivery systems.en_US
dc.description.sponsorshipNational Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (award number DMR – 0819762)en_US
dc.description.sponsorshipNational Institute on Aging (grant number 5R01AG029601-03)en_US
dc.description.sponsorshipNational Institute of Dental and Craniofacial Research (U.S.) (grant number 5R01AG029601-03)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/cm102578jen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleElectrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coatingen_US
dc.typeArticleen_US
dc.identifier.citationSchmidt, Daniel J., Joshua S. Moskowitz, and Paula T. Hammond 2010Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating. Chemistry of Materials 22(23): 6416–6425.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.mitauthorSchmidt, Daniel J.en_US
dc.contributor.mitauthorMoskowitz, Joshua Sethen_US
dc.contributor.mitauthorHammond, Paula T.en_US
dc.relation.journalChemistry of Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSchmidt, Daniel J.; Moskowitz, Joshua S.; Hammond, Paula T.en_US
dspace.mitauthor.errortrue
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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