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Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

Author(s)
Tong, Rong; Hemmati, Houman D.; Langer, Robert; Kohane, Daniel S.
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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Abstract
We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, which undergoes reversible photoisomerization, and PEGylated lipid enables repetitive dosing from a single administration and enhances tissue penetration. The photoswitching allows particles to fluoresce and release drugs inside cells when illuminated with UV light. The mechanism of the light-induced size switching and triggered-release is studied. These particles provide spatiotemporal control of drug release and enhanced tissue penetration, useful properties in many disease states including cancer.
Date issued
2012-03
URI
http://hdl.handle.net/1721.1/79103
Department
delete; David H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Chemical Engineering
Journal
Journal of the American Chemical Society
Citation
Tong, Rong, Houman D. Hemmati, Robert Langer, and Daniel S. Kohane 2012 "Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery." Journal of the American Chemical Society 134(21): 8848–8855. © 2012 American Chemical Society.
Version: Final published version
ISSN
0002-7863
1520-5126

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