MIT Libraries homeMIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Tunable spatial heterogeneity in structure and composition within aqueous microfluidic droplets

Author(s)
Hui, Sophia Lee Su; Wang, Pengzhi; Kun Yap, Swee; Hatton, T. Alan; Khan, Saif A.
Thumbnail
DownloadHatton_Tunable spatial.pdf (2.146Mb)
PUBLISHER_POLICY

Publisher Policy

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

Terms of use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Metadata
Show full item record
Abstract
In this paper, we demonstrate biphasic microfluidic droplets with broadly tunable internal structures, from simple near-equilibrium drop-in-drop morphologies to complex yet uniform non-equilibrium steady-state structures. The droplets contain an aqueous mixture of poly(ethylene glycol) (PEG) and dextran and are dispensed into an immiscible oil in a microfluidic T-junction device. Above a certain well-defined threshold droplet speed, the inner dextran-rich phase is “stirred” within the outer PEG-rich phase. The stirred polymer mixture is observed to exhibit a near continuum of speed and composition-dependent phase morphologies. There is increasing interest in the use of such aqueous two-phase systems in microfluidic devices for biomolecular applications in a variety of contexts. Our work presents a method to go beyond equilibrium phase morphologies in generating microfluidic “multiple” emulsions and at the same time raises the possibility of biochemical experimentation in benign yet complex biomimetic milieus.
Date issued
2012-04
URI
http://hdl.handle.net/1721.1/79363
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Singapore-MIT Alliance in Research and Technology (SMART)
Journal
Biomicrofluidics
Publisher
American Institute of Physics
Citation
Hui,Sophia Lee Su, Pengzhi Wang, Swee Kun Yap, T. Alan Hatton, and Saif A. Khan. Tunable Spatial Heterogeneity in Structure and Composition Within Aqueous Microfluidic Droplets. Biomicrofluidics 6, no. 2 (2012): 022005.
Version: Author's final manuscript
ISSN
19321058

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries homeMIT Libraries logo

Find us on

Twitter Facebook Instagram YouTube RSS

MIT Libraries navigation

SearchHours & locationsBorrow & requestResearch supportAbout us
PrivacyPermissionsAccessibility
MIT
Massachusetts Institute of Technology
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.