Nanowired three-dimensional cardiac patches
Author(s)
Dvir, Tal; Timko, Brian P.; Brigham, Mark D.; Naik, Shreesh R.; Karajanagi, Sandeep S.; Levy, Oren; Jin, Hongwei; Parker, Kevin K.; Kohane, Daniel S.; Langer, Robert S; ... Show more Show less
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Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds1, 2, 3. These biomaterials, which are usually made of either biological polymers such as alginate4 or synthetic polymers such as poly(lactic acid) (PLA)5, help cells organize into functioning tissues, but poor conductivity of these materials limits the ability of the patch to contract strongly as a unit6. Here, we show that incorporating gold nanowires within alginate scaffolds can bridge the electrically resistant pore walls of alginate and improve electrical communication between adjacent cardiac cells. Tissues grown on these composite matrices were thicker and better aligned than those grown on pristine alginate and when electrically stimulated, the cells in these tissues contracted synchronously. Furthermore, higher levels of the proteins involved in muscle contraction and electrical coupling are detected in the composite matrices. It is expected that the integration of conducting nanowires within three-dimensional scaffolds may improve the therapeutic value of current cardiac patches.
Date issued
2011-09Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MITJournal
Nature Nanotechnology
Publisher
Nature Publishing Group
Citation
Dvir, Tal, Brian P. Timko, Mark D. Brigham, Shreesh R. Naik, Sandeep S. Karajanagi, Oren Levy, Hongwei Jin, Kevin K. Parker, Robert Langer, and Daniel S. Kohane. Nanowired Three-dimensional Cardiac Patches. Nature Nanotechnology 6, no. 11 (September 25, 2011): 720-725.
Version: Author's final manuscript
ISSN
1748-3387
1748-3395