Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging
Author(s)Mieszawska, Aneta J.; Gianella, Anita; Cormode, David P.; Zhao, Yiming; Meijerink, Andries; Langer, Robert; Farokhzad, Omid C.; Fayad, Zahi A.; Mulder, Willem J. M.; ... Show more Show less
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Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate polymers modified with nanocrystals. The PLGA nanoparticles formed from modified PLGA polymers that were functionalized with either gold nanocrystals or quantum dots exhibited favorable features for computed tomography and optical imaging, respectively.
Departmentdelete; Massachusetts Institute of Technology. Department of Chemical Engineering
Royal Society of Chemistry
Mieszawska, Aneta J., Anita Gianella, David P. Cormode, Yiming Zhao, Andries Meijerink, Robert Langer, Omid C. Farokhzad, Zahi A. Fayad, and Willem J. M. Mulder. Engineering of Lipid-coated PLGA Nanoparticles with a Tunable Payload of Diagnostically Active Nanocrystals for Medical Imaging. Chemical Communications 48, no. 47 (2012): 5835.
Author's final manuscript