| dc.contributor.author | Su, Xingfang | |
| dc.contributor.author | Yang, Nicole Jie Yeon | |
| dc.contributor.author | Wittrup, Karl Dane | |
| dc.contributor.author | Irvine, Darrell J | |
| dc.date.accessioned | 2013-08-02T17:23:07Z | |
| dc.date.available | 2013-08-02T17:23:07Z | |
| dc.date.issued | 2013-04 | |
| dc.date.submitted | 2013-02 | |
| dc.identifier.issn | 1525-7797 | |
| dc.identifier.issn | 1526-4602 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/79767 | |
| dc.description.abstract | Plant-derived Type I toxins are candidate anticancer therapeutics requiring cytosolic delivery into tumor cells. We tested a concept for two-stage delivery, whereby tumor cells precoated with an antibody-targeted gelonin toxin were killed by exposure to endosome-disrupting polymer nanoparticles. Co-internalization of particles and tumor cell-bound gelonin led to cytosolic delivery and >50-fold enhancement of toxin efficacy. This approach allows the extreme potency of gelonin to be focused on tumors with significantly reduced potential for off-target toxicity. | en_US |
| dc.description.sponsorship | United States. Dept. of Defense (Institute for Soldier Nanotechnology, contract W911NF-07-D-0004) | en_US |
| dc.description.sponsorship | Howard Hughes Medical Institute (Investigator) | en_US |
| dc.description.sponsorship | Singapore. Agency for Science, Technology and Research | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/bm3019906 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Su, Xingfang, Nicole Yang, K. Dane Wittrup, and Darrell J. Irvine. Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles. Biomacromolecules 14, no. 4 (April 8, 2013): 1093-1102. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Materials Science and Engineering | en_US |
| dc.contributor.department | Ragon Institute of MGH, MIT and Harvard | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.mitauthor | Su, Xingfang | en_US |
| dc.contributor.mitauthor | Yang, Nicole Jie Yeon | en_US |
| dc.contributor.mitauthor | Wittrup, Karl Dane | en_US |
| dc.contributor.mitauthor | Irvine, Darrell J. | en_US |
| dc.relation.journal | Biomacromolecules | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Su, Xingfang; Yang, Nicole; Wittrup, K. Dane; Irvine, Darrell J. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-2398-5896 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-0882-7761 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
