dc.contributor.author | Quinn, David J. | |
dc.contributor.author | Pivkin, Igor | |
dc.contributor.author | Wong, Sophie Y. | |
dc.contributor.author | Chiam, Keng-Hwee | |
dc.contributor.author | Dao, Ming | |
dc.contributor.author | Karniadakis, George E. | |
dc.contributor.author | Suresh, Subra | |
dc.date.accessioned | 2013-08-08T18:55:07Z | |
dc.date.available | 2013-08-08T18:55:07Z | |
dc.date.issued | 2010-12 | |
dc.date.submitted | 2010-09 | |
dc.identifier.issn | 0090-6964 | |
dc.identifier.issn | 1573-9686 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/79817 | |
dc.description | Author manuscript; available in PMC 2012 March 1. | en_US |
dc.description.abstract | We investigate the biophysical characteristics of healthy human red blood cells (RBCs) traversing microfluidic channels with cross-sectional areas as small as 2.7 × 3 μm. We combine single RBC optical tweezers and flow experiments with corresponding simulations based on dissipative particle dynamics (DPD), and upon validation of the DPD model, predictive simulations and companion experiments are performed in order to quantify cell deformation and pressure–velocity relationships for different channel sizes and physiologically relevant temperatures. We discuss conditions associated with the shape transitions of RBCs along with the relative effects of membrane and cytosol viscosity, plasma environments, and geometry on flow through microfluidic systems at physiological temperatures. In particular, we identify a cross-sectional area threshold below which the RBC membrane properties begin to dominate its flow behavior at room temperature; at physiological temperatures this effect is less profound. | en_US |
dc.description.sponsorship | Singapore-MIT Alliance for Research and Technology | en_US |
dc.description.sponsorship | United States. National Institutes of Health (National Heart, Lung, and Blood Institute Award R01HL094270) | en_US |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1007/s10439-010-0232-y | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike 3.0 | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | en_US |
dc.source | PubMed Central | en_US |
dc.title | Combined Simulation and Experimental Study of Large Deformation of Red Blood Cells in Microfluidic Systems | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Quinn, David J., Igor Pivkin, Sophie Y. Wong, Keng-Hwee Chiam, Ming Dao, George Em Karniadakis, and Subra Suresh. “Combined Simulation and Experimental Study of Large Deformation of Red Blood Cells in Microfluidic Systems.” Annals of Biomedical Engineering 39, no. 3 (March 14, 2011): 1041-1050. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Materials Science and Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
dc.contributor.mitauthor | Quinn, David J. | en_US |
dc.contributor.mitauthor | Pivkin, Igor | en_US |
dc.contributor.mitauthor | Wong, Sophie Y. | en_US |
dc.contributor.mitauthor | Dao, Ming | en_US |
dc.contributor.mitauthor | Suresh, Subra | en_US |
dc.relation.journal | Annals of Biomedical Engineering | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Quinn, David J.; Pivkin, Igor; Wong, Sophie Y.; Chiam, Keng-Hwee; Dao, Ming; Karniadakis, George Em; Suresh, Subra | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-6223-6831 | |
mit.license | OPEN_ACCESS_POLICY | en_US |
mit.metadata.status | Complete | |