Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization
Author(s)Haze, Olesya; Smith, Albert A.; Corzilius, Bjorn; Griffin, Robert Guy; Swager, Timothy M
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The synthesis of air-stable, highly water-soluble organic radicals containing a 1,3-bis(diphenylene)-2-phenylallyl (BDPA) core is reported. A sulfonated derivative, SA-BDPA, retains the narrow electron paramagnetic resonance linewidth (<30 MHz at 5 T) of the parent BDPA in highly concentrated glycerol/water solutions (40 mM), which enables its use as polarizing agent for solid effect dynamic nuclear polarization (SE DNP). A sensitivity enhancement of 110 was obtained in high-field magic-angle-spinning (MAS) NMR experiments. The ease of synthesis and high maximum enhancements obtained with the BDPA-based radicals constitute a major advance over the trityl-type narrow-line polarization agents.
DepartmentMassachusetts Institute of Technology. Department of Chemistry; Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology)
Journal of the American Chemical Society
American Chemical Society (ACS)
Haze, Olesya, Björn Corzilius, Albert A. Smith, Robert G. Griffin, and Timothy M. Swager. “Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization.” Journal of the American Chemical Society 134, no. 35 (September 5, 2012): 14287-14290.
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