350-μm side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus
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Miniature endoscopic probes offer a solution for deep brain imaging by overcoming the limited depth of intravital microscopy. We describe a small-diameter (350 μm) graded-index optical probe with a side-view design for in vivo cellular imaging of the mammalian brain. The side-view probe provides a unique view of the vertical network of neurons and penetrating blood vessels. At a given insertion site, the translational and rotational scanning of the probe provides access to a large tissue area (>1 mm[superscript 2]) across the cortex, hippocampus, thalamus, and hypothalamus.
Date issued
2013-04Department
Harvard University--MIT Division of Health Sciences and TechnologyJournal
Journal of Biomedical Optics
Publisher
SPIE
Citation
Kim, Jun Ki. “350-<italic>μ</italic>m side-view optical probe for imaging the murine brain <italic>in vivo</italic> from the cortex to the hypothalamus.” Journal of Biomedical Optics 18, no. 5 (May 1, 2013): 050502. © 2013 Society of Photo-Optical Instrumentation Engineers
Version: Final published version
ISSN
1083-3668
1560-2281