Palladium(0)-Catalyzed Intermolecular Amination of Unactivated C[3 over sp]-H Bonds
Author(s)Pan, Jun; Su, Mingjuan; Buchwald, Stephen Leffler
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Filling out the space: The title reaction of unactivated C[3 over sp]-H bonds using aryl amines as the nitrogen source is disclosed (see scheme; dba=dibenzylideneacetone, Tf=trifluoromethanesulfonyl). Either the C-N cross-coupling product or the C-H amination product could be accessed selectively by adjusting the steric environment of the substrate.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie International Edition
Pan, Jun, Mingjuan Su, and Stephen L. Buchwald. “Palladium(0)-Catalyzed Intermolecular Amination of Unactivated C[3 over sp]-H Bonds.” Angewandte Chemie International Edition 50, no. 37 (September 5, 2011): 8647-8651.
Author's final manuscript