Combined Oxypalladation/C-H Functionalization: Palladium(II)-Catalyzed Intramolecular Oxidative Oxyarylation of Hydroxyalkenes
Author(s)Zhu, Rong; Buchwald, Stephen Leffler
MetadataShow full item record
An efficient protocol has been developed for the intramolecular oxidative oxyarylation using a Pd[superscript II]-catalyzed tandem oxypalladation/C-H functionalization strategy. This methodology allows rapid access to tetrahydro-2H-indeno-[2,1-b]furan frameworks from simple hydroxyalkenes. The reactivity of this process is orthogonal to that of Pd[superscript 0]-catalyzed transformations, enabling the divergent modification of a single molecule.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie International Edition
Zhu, Rong, and Stephen L. Buchwald. “Combined Oxypalladation/C-H Functionalization: Palladium(II)-Catalyzed Intramolecular Oxidative Oxyarylation of Hydroxyalkenes.” Angewandte Chemie International Edition 51, no. 8 (February 20, 2012): 1926-1929.
Author's final manuscript