Combined Oxypalladation/C-H Functionalization: Palladium(II)-Catalyzed Intramolecular Oxidative Oxyarylation of Hydroxyalkenes

Author(s)
Zhu, Rong; Buchwald, Stephen Leffler
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Abstract
An efficient protocol has been developed for the intramolecular oxidative oxyarylation using a Pd[superscript II]-catalyzed tandem oxypalladation/C-H functionalization strategy. This methodology allows rapid access to tetrahydro-2H-indeno-[2,1-b]furan frameworks from simple hydroxyalkenes. The reactivity of this process is orthogonal to that of Pd[superscript 0]-catalyzed transformations, enabling the divergent modification of a single molecule.
Date issued
2012-01
URI
http://hdl.handle.net/1721.1/81951
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Zhu, Rong, and Stephen L. Buchwald. “Combined Oxypalladation/C-H Functionalization: Palladium(II)-Catalyzed Intramolecular Oxidative Oxyarylation of Hydroxyalkenes.” Angewandte Chemie International Edition 51, no. 8 (February 20, 2012): 1926-1929.
Version: Author's final manuscript
ISSN
14337851
1521-3773
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