Me[subscript 3](OMe)tBuXPhos: A Surrogate Ligand for Me[subscript 4]tBuXPhos in Palladium-Catalyzed C-N and C-O Bond-Forming Reactions
Author(s)Ueda, Satoshi; Fors, Brett P.; Ali, Siraj Z.; Buchwald, Stephen Leffler
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A new biarylphosphine ligand, Me[subscript 3](OMe)tBuXPhos (L3), was designed as a surrogate for Me[subscript 4]tBuXPhos (L1). The Me[subscript 3](OMe)tBuXPhos could be prepared in a chromatography-free manner from inexpensive and readily available 2,3,6-trimethylphenol. Comparative studies demonstrated that a catalyst based on Me[subscript 3](OMe)tBuXPhos displayed the same reactivity as a catalyst based on Me[subscript 4]tBuXPhos for Pd-catalyzed C–N and C–O bond-forming processes.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
The Journal of Organic Chemistry
American Chemical Society (ACS)
Ueda, Satoshi, Siraj Ali, Brett P. Fors, and Stephen L. Buchwald. “Me3(OMe)tBuXPhos: A Surrogate Ligand for Me4tBuXPhos in Palladium-Catalyzed C–N and C–O Bond-Forming Reactions.” The Journal of Organic Chemistry 77, no. 5 (March 2, 2012): 2543-2547.
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