Pd-Catalyzed Synthesis of Ar-SCF3 Compounds under Mild Conditions
Author(s)Teverovskiy, Georgiy; Surry, David S.; Buchwald, Stephen Leffler
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Good to excellent yields of aryl trifluoromethyl sulfides, which are an important class of compounds in both the pharmaceutical and agrochemical areas, can be achieved under mild conditions by the Pd-catalyzed reaction of aryl bromides with a trifluoromethylthiolate nucleophile (see scheme).
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie International Edition
Teverovskiy, Georgiy, David S. Surry, and Stephen L. Buchwald. “Pd-Catalyzed Synthesis of Ar-SCF3 Compounds under Mild Conditions.” Angewandte Chemie International Edition 50, no. 32 (August 1, 2011): 7312-7314.
Author's final manuscript