Catalyst-Controlled Chemoselective Arylation of 2-Aminobenzimidazoles

Author(s)
Ueda, Satoshi; Buchwald, Stephen Leffler
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Abstract
What N would you like? The chemoselective and complementary Pd- and Cu-catalyzed N-arylation of 2-aminobenzimidazoles is described. Selective N-arylation of the amino group was achieved with a Pd-catalyzed method, while selective N-arylation of azole nitrogen was achieved with a Cu-catalyzed procedure (see scheme).
Date issued
2012-09
URI
http://hdl.handle.net/1721.1/81968
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Ueda, Satoshi, and Stephen L. Buchwald. “Catalyst-Controlled Chemoselective Arylation of 2-Aminobenzimidazoles.” Angewandte Chemie International Edition 51, no. 41 (October 8, 2012): 10364-10367.
Version: Author's final manuscript
ISSN
14337851
1521-3773
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