Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots
Author(s)
Choi, Hak Soo; Ipe, Binil Itty; Misra, Preeti; Lee, Jeong Heon; Bawendi, Moungi G.; Frangioni, John V.; ... Show more Show less
DownloadBawendi_Tissue- and organ-selective.pdf (2.202Mb)
PUBLISHER_POLICY
Publisher Policy
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Terms of use
Metadata
Show full item recordAbstract
A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
Date issued
2009-05Department
Massachusetts Institute of Technology. Department of ChemistryJournal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Choi, Hak Soo, Binil Itty Ipe, Preeti Misra, Jeong Heon Lee, Moungi G. Bawendi, and John V. Frangioni. “Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots.” Nano Letters 9, no. 6 (June 10, 2009): 2354-2359.
Version: Author's final manuscript
ISSN
1530-6984
1530-6992