Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots

Author(s)
Choi, Hak Soo; Ipe, Binil Itty; Misra, Preeti; Lee, Jeong Heon; Bawendi, Moungi G.; ... Show more
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Abstract
A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
Date issued
2009-05
URI
http://hdl.handle.net/1721.1/81986
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Choi, Hak Soo, Binil Itty Ipe, Preeti Misra, Jeong Heon Lee, Moungi G. Bawendi, and John V. Frangioni. “Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots.” Nano Letters 9, no. 6 (June 10, 2009): 2354-2359.
Version: Author's final manuscript
ISSN
1530-6984
1530-6992
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