Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots
Author(s)Choi, Hak Soo; Ipe, Binil Itty; Misra, Preeti; Lee, Jeong Heon; Bawendi, Moungi G.; Frangioni, John V.; ... Show more Show less
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A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Choi, Hak Soo, Binil Itty Ipe, Preeti Misra, Jeong Heon Lee, Moungi G. Bawendi, and John V. Frangioni. “Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots.” Nano Letters 9, no. 6 (June 10, 2009): 2354-2359.
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