The development of endo-selective epoxide-opening cascades in water
Author(s)Morten, Christopher J.; Byers, Jeffery A.; Van Dyke, Aaron R.; Vilotijevic, Ivan; Jamison, Timothy F.
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This tutorial review traces the development of endo-regioselective epoxide-opening reactions in water. Templated, water-promoted epoxide-opening cyclization reactions can offer rapid access to subunits of the ladder polyethers, a fascinating and complex family of natural products. This review may be of interest to those curious about the ladder polyethers and their hypothesized biogenesis, about organic reactions in water, and about the development and application of cascade reactions in organic synthesis.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Chemical Society Reviews
Royal Society of Chemistry, The
Morten, Christopher J., Jeffery A. Byers, Aaron R. Van Dyke, Ivan Vilotijevic, and Timothy F. Jamison. “The development of endo-selective epoxide-opening cascades in water.” Chemical Society Reviews 38, no. 11 (2009): 3175.
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