dc.contributor.author | Lovejoy, Katherine S. | |
dc.contributor.author | Lippard, Stephen J. | |
dc.date.accessioned | 2013-11-15T19:58:47Z | |
dc.date.available | 2013-11-15T19:58:47Z | |
dc.date.issued | 2009-10 | |
dc.date.submitted | 2009-07 | |
dc.identifier.issn | 1477-9226 | |
dc.identifier.issn | 1477-9234 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/82144 | |
dc.description.abstract | The five platinum anticancer compounds currently in clinical use conform to structure–activity relationships formulated (M. J. Cleare and J. D. Hoeschele, Bioinorg. Chem., 1973, 2, 187–210) shortly after the discovery that cis-diamminedichloroplatinum(II), cisplatin, has antitumor activity in mice. These compounds are neutral platinum(II) species with two am(m)ine ligands or one bidentate chelating diamine and two additional ligands that can be replaced by water through aquation reactions. The resulting cations ultimately form bifunctional adducts on DNA. Information about the chemistry of these platinum compounds and correlations of their structures with anticancer activity have provided guidance for the design of novel anticancer drug candidates based on the proposed mechanisms of action. This article discusses advances in the synthesis and evaluation of such non-traditional platinum compounds, including cationic and tumor-targeting constructs. | en_US |
dc.description.sponsorship | National Cancer Institute (U.S.) (Grant CA34992) | en_US |
dc.language.iso | en_US | |
dc.publisher | Royal Society of Chemistry, The | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1039/b913896j | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike 3.0 | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | en_US |
dc.source | PMC | en_US |
dc.title | Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Lovejoy, Katherine S., and Stephen J. Lippard. “Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting.” Dalton Transactions, no. 48 (2009): 10651. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.mitauthor | Lovejoy, Katherine S. | en_US |
dc.contributor.mitauthor | Lippard, Stephen J. | en_US |
dc.relation.journal | Dalton Transactions | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Lovejoy, Katherine S.; Lippard, Stephen J. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-2693-4982 | |
mit.license | OPEN_ACCESS_POLICY | en_US |
mit.metadata.status | Complete | |