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dc.contributor.authorLovejoy, Katherine S.
dc.contributor.authorLippard, Stephen J.
dc.date.accessioned2013-11-15T19:58:47Z
dc.date.available2013-11-15T19:58:47Z
dc.date.issued2009-10
dc.date.submitted2009-07
dc.identifier.issn1477-9226
dc.identifier.issn1477-9234
dc.identifier.urihttp://hdl.handle.net/1721.1/82144
dc.description.abstractThe five platinum anticancer compounds currently in clinical use conform to structure–activity relationships formulated (M. J. Cleare and J. D. Hoeschele, Bioinorg. Chem., 1973, 2, 187–210) shortly after the discovery that cis-diamminedichloroplatinum(II), cisplatin, has antitumor activity in mice. These compounds are neutral platinum(II) species with two am(m)ine ligands or one bidentate chelating diamine and two additional ligands that can be replaced by water through aquation reactions. The resulting cations ultimately form bifunctional adducts on DNA. Information about the chemistry of these platinum compounds and correlations of their structures with anticancer activity have provided guidance for the design of novel anticancer drug candidates based on the proposed mechanisms of action. This article discusses advances in the synthesis and evaluation of such non-traditional platinum compounds, including cationic and tumor-targeting constructs.en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Grant CA34992)en_US
dc.language.isoen_US
dc.publisherRoyal Society of Chemistry, Theen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/b913896jen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePMCen_US
dc.titleNon-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targetingen_US
dc.typeArticleen_US
dc.identifier.citationLovejoy, Katherine S., and Stephen J. Lippard. “Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting.” Dalton Transactions, no. 48 (2009): 10651.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorLovejoy, Katherine S.en_US
dc.contributor.mitauthorLippard, Stephen J.en_US
dc.relation.journalDalton Transactionsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLovejoy, Katherine S.; Lippard, Stephen J.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-2693-4982
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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