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dc.contributor.authorCharoensawan, Varodom
dc.contributor.authorJanga, Sarath Chandra
dc.contributor.authorBulyk, Martha L.
dc.contributor.authorBabu, M. Madan
dc.contributor.authorTeichmann, Sarah A.
dc.date.accessioned2013-11-18T15:18:57Z
dc.date.available2013-11-18T15:18:57Z
dc.date.issued2012-07
dc.date.submitted2012-05
dc.identifier.issn10972765
dc.identifier.urihttp://hdl.handle.net/1721.1/82156
dc.description.abstractTranscription factors (TFs) and histone octamers are two abundant classes of DNA binding proteins that coordinate the transcriptional program in cells. Detailed studies of individual TFs have shown that TFs bind to nucleosome-occluded DNA sequences and induce nucleosome disruption/repositioning, while recent global studies suggest this is not the only mechanism used by all TFs. We have analyzed to what extent the intrinsic DNA binding preferences of TFs and histones play a role in determining nucleosome occupancy, in addition to nonintrinsic factors such as the enzymatic activity of chromatin remodelers. The majority of TFs in budding yeast have an intrinsic sequence preference overlapping with nucleosomal histones. TFs with intrinsic DNA binding properties highly correlated with those of histones tend to be associated with gene activation and might compete with histones to bind to genomic DNA. Consistent with this, we show that activators induce more nucleosome disruption upon transcriptional activation than repressors.en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.molcel.2012.06.028en_US
dc.rightsArticle is available under a Creative Commons license.en_US
dc.rights.urihttp://creativecommons.org/en_US
dc.sourcePMCen_US
dc.titleDNA Sequence Preferences of Transcriptional Activators Correlate More Strongly than Repressors with Nucleosomesen_US
dc.typeArticleen_US
dc.identifier.citationCharoensawan, Varodom, Sarath Chandra Janga, Martha L. Bulyk, M. Madan Babu, and Sarah A. Teichmann. “DNA Sequence Preferences of Transcriptional Activators Correlate More Strongly than Repressors with Nucleosomes.” Molecular Cell 47, no. 2 (July 2012): 183-192. © 2012 Elsevier Inc.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorBulyk, Martha L.en_US
dc.relation.journalMolecular Cellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsCharoensawan, Varodom; Janga, Sarath Chandra; Bulyk, Martha L.; Babu, M. Madan; Teichmann, Sarah A.en_US
mit.licensePUBLISHER_CCen_US


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