Concise total synthesis of (+)-gliocladins B and C
Author(s)Movassaghi, Mohammad; Boyer, Nicolas Cedric
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The first total synthesis of (+)-gliocladin B is described. Our concise and enantioselective synthesis takes advantage of a new regioselective Friedel–Crafts-based strategy to provide an efficient multigram-scale access to the C3-(3′-indolyl)hexahydropyrroloindole substructure, a molecular foundation present in a significant subset of epipolythiodiketopiperazine natural alkaloids. Our first-generation solution to (+)-gliocladin B involved the stereoselective formation of (+)-12-deoxybionectin A, a plausible biosynthetic precursor. Our synthesis clarified the C15 stereochemistry of (+)-gliocladin B and allowed its full structure confirmation. Further studies of a versatile dihydroxylated diketopiperazine provided a concise and efficient synthesis of (+)-gliocladin B as well as access to (+)-gliocladin C.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Royal Society of Chemistry, The
Boyer, Nicolas, and Mohammad Movassaghi. “Concise total synthesis of (+)-gliocladins B and C.” Chemical Science 3, no. 6 (2012): 1798.
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