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Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites

Author(s)
Lo, Justin H.; Douglass, Jacqueline; Park, Ji-Ho; Sailor, Michael J.; Ruoslahti, Erkki; Bhatia, Sangeeta N; von Maltzhan, Geoffrey; ... Show more Show less
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Abstract
The success of nanoparticle-based cancer therapies ultimately depends on their ability to selectively and efficiently accumulate in regions of disease. Outfitting nanoparticles to actively target tumor-specific markers has improved specificity, yet it remains a challenge to amass adequate therapy in a selective manner. To help address this challenge, we have developed a mechanism of nanoparticle amplification based on stigmergic (environment-modifying) signalling, in which a “Signalling” population of gold nanorods induces localized unveiling of cryptic collagen epitopes, which are in turn targeted by “Responding” nanoparticles bearing gelatin-binding fibronectin fragments. We demonstrate that this two-particle system results in significantly increased, selective recruitment of responding particles. Such amplification strategies have the potential to overcome limitations associated with single-particle targeting by leveraging the capacity of nanoparticles to interact with their environment to create abundant new binding motifs.
Date issued
2013-06
URI
http://hdl.handle.net/1721.1/82619
Department
Whitaker College of Health Sciences and Technology; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Koch Institute for Integrative Cancer Research at MIT
Journal
Journal of Materials Chemistry B
Publisher
Royal Society of Chemistry
Citation
Lo, Justin H., Geoffrey von Maltzahn, Jacqueline Douglass, Ji-Ho Park, Michael J. Sailor, Erkki Ruoslahti, and Sangeeta N. Bhatia. “Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites.” Journal of Materials Chemistry B 1, no. 39 (2013): 5235. © Royal Society of Chemistry 2013
Version: Final published version
ISSN
2050-750X
2050-7518

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