Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
Author(s)Cheeseman, Iain McPherson
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The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Earnshaw, W. C., R. C. Allshire, B. E. Black, K. Bloom, B. R. Brinkley, W. Brown, I. M. Cheeseman, et al. “Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.” Chromosome Research 21, no. 2 (April 12, 2013): 101-106.
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