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Aneuploidy Drives Genomic Instability in Yeast

dc.contributor.authorSheltzer, Jason Meyer
dc.contributor.authorBlank, Heidi Marie
dc.contributor.authorPfau, Sarah Jeanne
dc.contributor.authorTange, Yoshie
dc.contributor.authorGeorge, Benson M.
dc.contributor.authorHumpton, Timothy J.
dc.contributor.authorBrito, Ilana Lauren
dc.contributor.authorHiraoka, Yasushi
dc.contributor.authorNiwa, Osami
dc.contributor.authorAmon, Angelika B
dc.date.accessioned2013-12-10T21:45:03Z
dc.date.available2013-12-10T21:45:03Z
dc.date.issued2011-08
dc.date.submitted2011-03
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/1721.1/82910
dc.description.abstractAneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.en_US
dc.language.isoen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/science.1206412en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePMCen_US
dc.titleAneuploidy Drives Genomic Instability in Yeasten_US
dc.typeArticleen_US
dc.identifier.citationSheltzer, J. M., H. M. Blank, S. J. Pfau, Y. Tange, B. M. George, T. J. Humpton, I. L. Brito, Y. Hiraoka, O. Niwa, and A. Amon. “Aneuploidy Drives Genomic Instability in Yeast.” Science 333, no. 6045 (August 18, 2011): 1026-1030.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorSheltzer, Jason Meyeren_US
dc.contributor.mitauthorBlank, Heidi Marieen_US
dc.contributor.mitauthorPfau, Sarah Jeanneen_US
dc.contributor.mitauthorGeorge, Benson M.en_US
dc.contributor.mitauthorHumpton, Timothy J.en_US
dc.contributor.mitauthorAmon, Angelika B.en_US
dc.relation.journalScienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSheltzer, J. M.; Blank, H. M.; Pfau, S. J.; Tange, Y.; George, B. M.; Humpton, T. J.; Brito, I. L.; Hiraoka, Y.; Niwa, O.; Amon, A.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-4698-2746
dc.identifier.orcidhttps://orcid.org/0000-0001-9837-0314
dc.identifier.orcidhttps://orcid.org/0000-0003-1381-1323
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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