Putting Two Heads Together to Unwind DNA
Author(s)Takara, Thomas J.; Bell, Stephen P.; Takara,Thomas J.
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The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2–7 replicative helicase encircles double-stranded DNA as head-to-head double hexamers.
DepartmentMassachusetts Institute of Technology. Department of Biology
Takara, Thomas J., and Stephen P. Bell. “Putting Two Heads Together to Unwind DNA.” Cell 139, no. 4 (November 2009): 652-654. http://dx.doi.org/10.1016/j.cell.2009.10.037. © 2009 Elsevier Inc.
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