Show simple item record

dc.contributor.authorKwiatkowski, Adam V.
dc.contributor.authorRubinson, Douglas A.
dc.contributor.authorDent, Erik W.
dc.contributor.authorEdward van Veen, J.
dc.contributor.authorLeslie, Jonathan D.
dc.contributor.authorZhang, Jiangyang
dc.contributor.authorMebane, Leslie Marie
dc.contributor.authorPhilippar, Ulrike
dc.contributor.authorPinheiro, Elaine M.
dc.contributor.authorBurds, Aurora A.
dc.contributor.authorBronson, Roderick T.
dc.contributor.authorMori, Susumu
dc.contributor.authorGertler, Frank
dc.contributor.authorFassler, Reinhard
dc.date.accessioned2014-01-06T18:55:02Z
dc.date.available2014-01-06T18:55:02Z
dc.date.issued2007-11
dc.date.submitted2007-07
dc.identifier.issn08966273
dc.identifier.issn1097-4199
dc.identifier.urihttp://hdl.handle.net/1721.1/83509
dc.description.abstractMammalian cortical development involves neuronal migration and neuritogenesis; this latter process forms the structural precursors to axons and dendrites. Elucidating the pathways that regulate the cytoskeleton to drive these processes is fundamental to our understanding of cortical development. Here we show that loss of all three murine Ena/VASP proteins, a family of actin regulatory proteins, causes neuronal ectopias, alters intralayer positioning in the cortical plate, and, surprisingly, blocks axon fiber tract formation during corticogenesis. Cortical fiber tract defects in the absence of Ena/VASP arise from a failure in neurite initiation, a prerequisite for axon formation. Neurite initiation defects in Ena/VASP-deficient neurons are preceded by a failure to form bundled actin filaments and filopodia. These findings provide insight into the regulation of neurite formation and the role of the actin cytoskeleton during cortical development.en_US
dc.description.sponsorshipAnna Fuller Foundation (Predoctoral Fellowship)en_US
dc.description.sponsorshipVirginia and Daniel K. Ludwig Graduate Fellowshipen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant F32-NS45366)en_US
dc.description.sponsorshipStanley Medical Research Instituteen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant GM58801)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant U54 GM064346)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.neuron.2007.09.008en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevier Open Archiveen_US
dc.titleEna/VASP Is Required for Neuritogenesis in the Developing Cortexen_US
dc.typeArticleen_US
dc.identifier.citationKwiatkowski, Adam V., Douglas A. Rubinson, Erik W. Dent, J. Edward van Veen, Jonathan D. Leslie, Jiangyang Zhang, Leslie M. Mebane, et al. “Ena/VASP Is Required for Neuritogenesis in the Developing Cortex.” Neuron 56, no. 3 (November 2007): 441-455. Copyright © 2007 Elsevier Inc.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorKwiatkowski, Adam V.en_US
dc.contributor.mitauthorRubinson, Douglas A.en_US
dc.contributor.mitauthorDent, Erik W.en_US
dc.contributor.mitauthorEdward van Veen, J.en_US
dc.contributor.mitauthorLeslie, Jonathan D.en_US
dc.contributor.mitauthorMebane, Leslie Marieen_US
dc.contributor.mitauthorPhilippar, Ulrikeen_US
dc.contributor.mitauthorPinheiro, Elaine M.en_US
dc.contributor.mitauthorBurds, Aurora A.en_US
dc.contributor.mitauthorGertler, Franken_US
dc.relation.journalNeuronen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKwiatkowski, Adam V.; Rubinson, Douglas A.; Dent, Erik W.; Edward van Veen, J.; Leslie, Jonathan D.; Zhang, Jiangyang; Mebane, Leslie M.; Philippar, Ulrike; Pinheiro, Elaine M.; Burds, Aurora A.; Bronson, Roderick T.; Mori, Susumu; Fässler, Reinhard; Gertler, Frank B.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-6738-2435
dc.identifier.orcidhttps://orcid.org/0000-0001-8525-7136
dc.identifier.orcidhttps://orcid.org/0000-0003-3214-4554
dspace.mitauthor.errortrue
mit.licensePUBLISHER_POLICYen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record