The SirT3 Divining Rod Points to Oxidative Stress
Author(s)Bell, Eric L.; Guarente, Leonard Pershing
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Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative stress. This review focuses on new data linking SirT3 to management of reactive oxygen species from mitochondria, which may have profound implications for aging and late-onset diseases.
DepartmentMassachusetts Institute of Technology. Department of Biology; Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology)
Bell, Eric L., and Leonard Guarente. “The SirT3 Divining Rod Points to Oxidative Stress.” Molecular Cell 42, no. 5 (June 2011): 561-568. Copyright © 2011 Elsevier Inc.
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