Metastatic Cells Will Take Any Help They Can Get
Author(s)Hynes, Richard O
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Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. Second, VCAM-1 allows dormant tumor cells to interact with osteoclasts, yielding paracrine signals and enhancing osteolytic metastatic growth.
DepartmentMassachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Hynes, Richard O. “Metastatic Cells Will Take Any Help They Can Get.” Cancer Cell 20, no. 6 (December 2011): 689-690. Copyright © 2011 Elsevier Inc.
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