Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides
Author(s)Shen, Bo; Jamison, Timothy F.
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A new photochemical flow reactor has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2′-deoxy and 2′,3′-dideoxynucleosides. The continuous flow format significantly improved both the efficiency and selectivity of the reaction, with the streamlined multi-step sequence directly furnishing the highly desired unprotected deoxynucleosides.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Australian Journal of Chemistry
Shen, Bo, and Timothy F. Jamison. “Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides.” Australian Journal of Chemistry 66, no. 2 (2013): 157.
Author's final manuscript