Continuous flow photocatalysis enhanced using an aluminum mirror: rapid and selective synthesis of 2′-deoxy and 2′,3′-dideoxynucleosides

Author(s)
Shen, Bo; Bedore, Matthew W.; Sniady, Adam; Jamison, Timothy F.
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Abstract
A unique photochemical flow reactor featuring quartz tubing, an aluminum mirror and temperature control has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2′-deoxy and 2′,3′-dideoxynucleosides. The continuous flow format significantly increased the efficiency and selectivity of the reaction.
Date issued
2012-06
URI
http://hdl.handle.net/1721.1/84618
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Chemical Communications
Publisher
Royal Society of Chemistry
Citation
Shen, Bo, Matthew W. Bedore, Adam Sniady, and Timothy F. Jamison. “Continuous flow photocatalysis enhanced using an aluminum mirror: rapid and selective synthesis of 2′-deoxy and 2′,3′-dideoxynucleosides.” Chemical Communications 48, no. 60 (2012): 7444.
Version: Author's final manuscript
ISSN
1359-7345
1364-548X
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